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Program
Speakers
Speaker presentation titles and abstracts
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List of publications citing PAMPA
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| Sunday, July 14th |
| 8:00-9:00 |
Registration and Check-in for Short Course and Symposium |
| 9:00-4:00 |
Short Course "Accurate Determination of Physical Chemical Properties in Drug Discovery". |
| 3:00-8:00 |
Registration and Check-in for Symposium |
| 6:00-7:00 |
Reception - California Wine and Cheese |
| 7:00-8:00 |
Buffet Dinner |
| 8:00-9:00 |
Per Artursson, University of Uppsala, Sweden
"Prediction of Drug Absorption: Caco-2 and Beyond" |
| 9:00-10:00 |
Social Mixer |
| Monday, July 15th |
| 7:00-9:00 |
Registration and Check-in for Symposium |
| 7:00-8:00 |
pION Sales Meeting - Chair Mark Gelo |
| 8:00-8:55 |
Continental Breakfast |
| 9:00-12:30 |
Session One - Chair Alex Avdeef |
| 9:00-9:05 |
Opening Remarks |
| 9:05-9:50 |
Manfred Kansy, Hoffmann-La Roche, Basel, CH
"Parallel Artificial Membrane Permeability Screening in the Framework of Multidimensional Optimization of Drug Candidates - An Overview"
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| 9:50-10:35 |
Bernard Faller, Novartis, Basel, CH
"High-throughput Permeability & High-throughput logP with Artificial Membranes"
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| 10:35-11:00 |
Coffee Break |
| 11:00-11:45 |
Kiyohiko Sugano, Chugai Pharmaceuticals, Tokyo, JP
"BAMPA: Beyond the Physicochemical Profiling" |
| 11:45-12:30 |
Christian Schobert, Dow AgroSciences, Indianapolis, IN
"Bioavailability of Agrochemicals - The Role of Membrane Permeation" |
| 12:30-1:30 |
Lunch |
| 1:30-10:00 |
Wine Country Excursion with Dinner |
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| Tuesday, July 16th |
| 8:00-8:55 |
Continental Breakfast |
| 9:00-12:30 |
Session Two - Chair Manfred Kansy |
| 9:00-9:05 |
Opening Remarks |
| 9:05-9:50 |
Bradley Anderson, Univ. of Kentucky, Lexington, KY
"Effects of Permeant Structure and Bilayer Composition on Lipid Bilayer Permeability" |
| 9:50-10:35 |
Edward Kerns, Wyeth Research, Princeton, NJ
"Applications of PAMPA in Pharmaceutical Profiling for Exploratory and Discovery Drug Research" |
| 10:35-11:00 |
Coffee Break |
| 11:00-11:45 |
H-Y Cheng, GlaxoSmithKline, King of Prussia, PA
"The Integration of Membrane Permeability Assay into a Developability Process for Profiling Early Discovery Compounds" |
| 11:45-12:30 |
Cheng Zhu, Aventis Pharmaceuticals, Bridgewater, NJ
"How Confident Are We in PAMPA?" |
| 12:30-1:30 |
Lunch |
| 1:30-2:30 |
Session Three - Chair Jeffrey Ruell |
| 1:30-2:00 |
Marc Noppe, Johnson & Johnson PRD, Beerse, BE
"One Year Experience with PAMPA: Comparison between in silico Data, PAMPA and Animal Data" |
| 2:30-3:30 |
PSR4 User's Meeting - Chair Chau Du |
| 2:30-5:30 |
Poster Session and Sponsor Exhibits |
| 6:30-8:30 |
Symposium Dinner |
| 8:30-9:30 |
Norman F.H. Ho, University of Utah, Salt Lake City, UT
"Biophysical Model Approach to the Quantitation and Mechanistic Interpretation of Transepithelial Membrane Kinetics"
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| 9:30-10:30 |
Social Mixer |
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| Wednesday, July 17th |
| 8:00-8:55 |
Continental Breakfast |
| 9:00-12:30 |
Session Four - Chair Bernard Faller |
| 9:00-9:05 |
Opening Remarks |
| 9:00-9:50 |
Alex Avdeef, pION INC, Boston, MA
"PAMPA: Effects of Lipids, Solute Retention, Unstirred Water Layer, Buffers, Solute-Membrane Charge, Iso-pH, Gradient-pH, and the Double-Sink"
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| 9:50-10:35 |
Li Di, Wyeth Research, Princeton, NJ
"High Throughput Artificial Membrane Permeability Assay for Blood-Brain Barrier" |
| 10:35-11:00 |
Coffee Break |
| 11:00-11:45 |
James Polli, University of Maryland, Baltimore, MD
"Caco-2 Permeability: Methods and Its Use in Dosage Form Performance Evaluation, the Assessment of Excipient Effects,
and the Biopharmaceutics Classification System" |
| 11:45-12:30 |
Matt Wood, AstraZeneca, Loughborough, UK
"Investigation of the Physicochemical Parameters of the Parallel Artificial Membrane Permeability Assay (PAMPA) and their Optimization
for Drug Discovery" |
| 12:30-1:30 |
Lunch |
| 1:30-3:00 |
Session Five - Chair Edward Kerns |
| 1:30-3:00 |
Discussion Session - "Standardization, Caco-2 Coexistence and Where to Go From Here?" |
| 3:00-3:05 |
Closing Remarks - Alex Avdeef |
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Keynote Speaker
Manfred Kansy, F. Hoffmann-La Roche (Switzerland)
After-Dinner Speaker
Per Artursson, University of Uppsala (Sweden)
Norman F.H. Ho, University of Utah (USA)
Lead Speakers
Bernard Faller, Novartis Pharmaceuticals (Switzerland)
Kiyohiko Sugano, Chugai Pharmaceutical Co. Ltd (Japan)
Alex Avdeef, pION INC (USA)
Invited Speakers
Chengyue Zhu, Aventis Pharmaceuticals (USA)
HY Cheng, GlaxoSmithKline (USA)
Edward Kerns, Wyeth Research (USA)
Li Di, Wyeth Research (USA)
Christian Schobert, Dow AgroSciences (USA)
Marc Noppe, Johnson & Johnson PRD (Belgium)
Bradley Anderson, University of Kentucky (USA)
James Polli, University of Maryland (USA)
Matt Wood, AstraZeneca (UK)
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