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PAMPA2002 Symposium

Avdeef, A.; Bendels, S.; Tsinman, O.; Tsinman, K.; Kansy, M. Solubility-Excipient Classification Gradient Maps. Pharm. Res., 2007, 24, 530-545. (Part 22 in PAMPA series). Available on-line through SpringerLink.

Bendels, S.; Tsinman, O.; Wagner, B.; Lipp, D.; Parilla, I.; Kansy, M.; Avdeef, A. PAMPA-Excipient Classification Gradient Map. Pharm. Res., 2006, 23, 2525-2535. (Part 21 in PAMPA series). Available on-line through SpringerLink.

Avdeef, A. The Rise of PAMPA. Expert Opinion on Drug Metab. Tox., 2005, 1, 325-342. (Part 17 in PAMPA series)

Kansy, M.; Avdeef, A.; Fischer, H. Advances in Screening for Membrane Permeability: High-Resolution PAMPA for Medicinal Chemists. Drug Discovery Today: Technologies, 2005, 1, 349-355. (Part 16 in PAMPA series)

Ruell, J.A.; Avdeef, A. Absorption using the PAMPA Approach. In: Yan, Z.; Caldwell, G.W. (Eds.), Optimization in Drug Discovery: In Vitro Methods. The Humana Press: Totowa, NJ, 2004, pp. 37-64. (Part 15 in PAMPA series)

Avdeef, A. HT Solubility and Permeability: MAD-PAMPA Analysis. In: Kr@mer, S.D.; Folkers, G.; Testa, B. (Eds.), Physicochemical and Biological Profiling in Drug Research. Wiley-VCH: Weinheim, 2004, in press. (Part 14 in PAMPA series)

Avdeef, A.; Tsinman, O. PAMPA – a Drug Absorption in vitro Model. 13. Chemical Selectivity due to Membrane Hydrogen Bonding: in combo Comparisons of HDM-, DOPC-, and DS-PAMPA. Eur. J. Pharm. Sci., 2006, 28(1-2), 43-50. (Part 13 in PAMPA series)

Ruell, J.A.; Tsinman, O.; Avdeef, A. Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules. Chem. Pharm. Bull., 2004, 52, 561-565. (Part 12 in PAMPA series)

Avdeef, A.; Nielsen, P.E.; Tsinman, O. PAMPA - a Drug Absorption in vitro Model. 11. Matching the in vivo Unstirred Water Layer Thickness by Individual-Well Stirring in Microtitre Plates. Eur. J. Pharm. Sci., 2004, 22, 365-374. (Part 11 in PAMPA series)

Caron, G.; Ermondi, G.; Damiano, A.; Novaroli, L.; Tsinman, O.; Ruell, J.A.; Avdeef, A. Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine. Bioorg. Med. Chem., 2004, 23, 6107-6118. (Part 10 in PAMPA series)

Avdeef, A.; Artursson, P.; Neuhoff, S.; Lazarova, L.; GrDsj`, J.; Tavelin, S. Caco-2 Permeability of Weakly Basic Drugs Predicted with the Double-Sink PAMPA pKaflux Method. Layer. Eur. J. Pharm. Sci., 2005, 24, 333-349. (Part 9 in PAMPA series)

Nielsen, P.; Avdeef, A. PAMPA - a Drug Absorption in vitro Model. 8. Apparent Filter Porosity and the Unstirred Water Layer. Eur. J. Pharm. Sci., 2004, 22, 33-41. (Part 8 in PAMPA series)

Bermejo, M.; Avdeef, A.; Ruiz, A.; Nalda, R.; Ruell, J.A.; Tsinman, O.; Gonz<lez, I.; Fern<ndez, C.; S<nchez, G.; Garrigues, T.M.; Merino, V. PAMPA - a drug absorption in vitro model. 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur. J. Pharm. Sci., 2004, 21,429-441. (Part 7 in PAMPA series)

Youdim, K.A.; Avdeef, A.; Abbott, N.J. In vitro trans-monolayer permeability calculations: often forgotten assumptions. Drug Disc. Today, 2003, 8, 997-1003. (Part 6 in PAMPA series)

Ruell, J.A.; Tsinman, K.L.; Avdeef, A. PAMPA - a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKaflux - optimized design (pOD-PAMPA). Eur. J. Pharm. Sci., 2003, 20, 393-402 (Part 5 in PAMPA series)

Liu, H.; Sabus, C.; Carter, G.T; Du, C.; Avdeef, A.; Tischler, M. Solubilizer Selection in the parallel artificial membrane permeability assay (PAMPA) for in vitro permeability measurement of low solubility compounds. Pharm. Res., 2003, 20, 1820-1826. (Part 4 in PAMPA series)

Avdeef, A. High-throughput Measurement of Membrane Permeability. In: H. van de Waterbeemd, H. Lennernäs, P. Artursson (Eds.). Drug Bioavailability/Estimation of Solubility, Permeability, Absorption and Bioavailability. Wiley-VCH: Weinheim, 2003, pp. 46-71. (Part 3 in PAMPA series)

Avdeef, A.; Strafford, M.; Block, E.; Balogh, M.P.; Chambliss, W.; Khan, I. Drug Absorption In Vitro Model: Filter-Immobilized Artificial Membranes. 2. Studies of the Permeability Properties of Lactones in Piper methysticum Forst. Eur. J. Pharm. Sci., 2001, 14, 271-280. (Part 2 in PAMPA series)

Avdeef, A. High-throughput measurements of solubility profiles. In: Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R. (Eds.), Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta: Zürich and Wiley - VCH: Weinheim, 2001, pp. 305-326. (Part 1 in PAMPA series)

Avdeef, A.; Testa, B. Physicochemical profiling in drug research: a brief state-of-the-art of experimental techniques. Cell. Molec. Life Sci. 2003, 59, 1681-1689.

Bergström, C.A.S.; Strafford, M.; Lazarova, L.; Avdeef, A.; Luthman, K.; Artursson, P. Absorption classification of oral drugs based on molecular surface properties. J. Med. Chem., 2003, 46, 558-570.

Obata, K.; Sugano, K.; Sato, R.; Machida, M.; Saitoh, K. Profiling of Oral Drug Absorption by High-throughput Screening During the Early Drug Discovery Process. J. Pharm. Sci. Tech. Japan 2002, 62, 241.

Sugano, K.; Takata, N.; Machida, M.; Saitoh, K. Prediction of Total Passive Permeation Using Bio-mimetic Artificial Membrane Permeability and Paracellular Pathway Model. J. Pharm. Sci. Tech. Japan 2002, 62, 240.

Di, L. High-Throughput Physico-Chemical Profiling for Optimization of Drug like Properties. In: Exploiting Molecular Diversity. San Diego, CA, February 2002.

Mentzer, M.; Cheng, HY; Lin, F.; Bean, M.F.; Hemling, M.E.; Carr S.A. Quantitative Determination of Compound Permeability in an Artificial Membrane System with LC/MS Detection. In: 49th ASMS Conference. Chicago, IL, May 2001.

Avdeef, A.; Strafford, M.; Block, E.; Balogh, M.P.; Chambliss, W.; Khan, I. Drug Absorption In Vitro Model: Filter-Immobilized Artificial Membranes. 2. Studies of the Permeability Properties of Lactones in Piper methysticum Forst. Eur. J. Pharm. Sci. 2001, 14, 271-280.

Sugano, K.; Hamada, H.; Machida, M.; Ushio, H.; Saitoh, K.; Terada, K. Optimized Conditions of Bio-mimetic Artificial Membrane Permeability Assay. International Journal of Pharm. 2001, 228, 181-188.

Sugano, K.; Hamada, H.; Machida, M.; Ushio, H. High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay. J. Biomolec. Screen. 2001, 6, 189-196.

Hwang, K. Predictive artificial membrane technology for high throughput screening. In: New Technologies to Increase Drug Candidate Survivability Conference. SR Institute. 17-18 May 2001, Somerset, NJ.

Kerns, E.H. High Throughput Physicochemical Profiling for Drug Discovery. J. Pharm. Sci. 2001, 90, 1838-1858.

Wohnsland, F.; Faller, B. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J. Med. Chem. 2001, 44, 923-930.

Kansy, M.; Fischer, H.; Kratzat, K.; Senner, F.; Wagner, B.; Parrilla, I. High-throughput artificial membrane permeability studies in early lead discovery and development. In: Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R. (Eds.), Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta: Zürich and Wiley - VCH: Weinheim, 2001, pp. 447-464.

Avdeef, A. High-Throughput Measurement of Solubility Profiles. In: Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R. (Eds.), Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta: Zürich and Wiley - VCH: Weinheim, 2001, pp. 305-326.

Faller, B.; Wohnsland, F. Physicochemical Parameters as Tools in Drug Discovery and Lead Optimization. In: Testa, B., van de Waterbeemd, H., Folkers, G., Guy, R. (Eds.), Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta: Zürich and Wiley - VCH: Weinheim, 2001, pp. 257-274.

Zhu, C.; Chen, T.-M.; Hwang, K. A comparative study of parallel artificial membrane permeability assay for passive absorption screening. In: CPSA2000: The Symposium on Chemical and Pharmaceutical Structure Analysis. Milestone Development Services. Princeton, NJ, 26-28 Sept 2000.

Johnson, S.; Lin, F.; Cheng, HY; Hung, S.; Saunders, J.; Zheng, W.; Seibel, G. Using Molecular Structure to Assess Permeability in a Discovery Setting. In: 220th ACS National Meeting. Washington, DC, Aug 2000.

Xu, R.; Nemes, C.; Liu, C. Z. C.; Kassel, D. B. A High Throughput Parallel LC/MS Method for Assessing Metabolic Stability and Permeability of Compound Libraries. In: 47th ASMS Conf. Mass Spectrometry and Allied Topics, Dallas, TX, 1999.

Kansy, M.; Senner, F.; Gubernator, K. Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeability Assay in the Description of Passive Absorption Processes. J. Med. Chem. 1998, 41, 1007-1010.

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